Question: What is the finest topology on $\mathrm{CAlg}$ (commutative ring spectra) for which $THH$THH (Topological Hochschild Homology) satisfies descent?
Adaptations of the arguments appearing in Section 3 of BMS2 show that $THH$THH has flat descent for simplicial commutative rings. However, the methods therein cannot be used to check whether $THH$THH has flat (or any weaker form of) descent for commutative ring spectra; simplicial $R$-algebras have the special property of being the nonabelian derived category of the category of finitely generated polynomial $R$-algebras.