For a positive integer $n$ we denote its largest prime factor by $\operatorname{gpf}(n)$. Let's call a pair of distinct primes $(p,q)$ $\textbf{nice}$ if there are no natural numbers $n$ such that $\operatorname{gpf}(n)=p, \operatorname{gpf}(n+1)=q$ or $\operatorname{gpf}(n)=q, \operatorname{gpf}(n+1)=p$. For example, $(2,19)$ is nice.

Are there nice pairs $(p,q)$ with $p,q>100$?

For a positive integer $n$ we denote its largest prime factor by $\operatorname{gpf}(n)$. Let's call a pair of distinct primes $(p,q)$ $\textbf{nice}$ if there are no natural numbers $n$ such that $\operatorname{gpf}(n)=p, \operatorname{gpf}(n+1)=q$ or $\operatorname{gpf}(n)=q, \operatorname{gpf}(n+1)=p$. For example, $(2,23)$ is nice.

Are there nice pairs $(p,q)$ with $p,q>100$?