I'm surprised this hasn't been posted yet:
Lusztig's conjecture in modular representation theory, which would describe the characters of simple $G_1$-modules for $p$ larger than the Coxeter number, was generally believed to be true for a long time. Here $G$ is a reductive algebraic group in characteristic $p$ and $G_1$ is its Frobenius kernel. The conjecture in turn leads to character formulae (or at least, algorithms for calculating characters) for simple representations of $G$.
They were proven for large $p$ by Andersen-Jantzen-Soergel, with later contributions by others, including an explicit bound by Fiebig. But recently Geordie Williamson proved that the original condition on $p$ is not enough.
See What to do now that Lusztig's and James' conjectures have been shown to be false? for more details.