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Emerton
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The top dimensional cohomology of a connected manifold is non-zero if and only if the manifold is compact, so the answer is "yes" for homology spheres.

EDIT: As Mariano remarks below, "compact" should read "compact and orientable".

The top dimensional cohomology of a connected manifold is non-zero if and only if the manifold is compact, so the answer is "yes" for homology spheres.

The top dimensional cohomology of a connected manifold is non-zero if and only if the manifold is compact, so the answer is "yes" for homology spheres.

EDIT: As Mariano remarks below, "compact" should read "compact and orientable".

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Emerton
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The top dimensional cohomology of a connected manifold is non-zero if and only if the manifold is compact, so the answer is "yes" for homology spheres.