[Added] Some comments intended to give some kind of relation with the answer provided by fpqc. My suggested answer is not homotopy invariant in the sense that a weak (or even homotopy) equivalence of simplicial sets does not induce an equivalence on the category of sheaves. This is so however if one, as per above, adds the condition that all the maps $T_{f(c)} \to T_c$ are isomorphisms. However, that condition is not so good as many maps that are not weak equivalences induces category equivalences (it is enough that the map induce isomorphisms on $\pi_0$ and $\pi_1$). This is a well-known phenomenon and has to do with the fact the $T_c$ are just sets. One could go further and assume that the $T_c$ are topological spaces and the maps $T_{f(c)} \to T_c$ continuous. Of course adding the condition that these maps be homeomorphisms shouldn't be right thing to do, instead one should demand that they be homotopy (or weak) equivalences. Again, this shouldn't be quite it because of the transitivity conditions. We should not have that the composite $T_{g(f(c))} \to T_{f(c)} \to T_c$ should be equal to $T_{g(f(c))} \to T_c$ but rather homotopic to it. Once we have opened that can of worms we should impose higher homotopies between repeated composites. This can no doubt be (has been) done but there seems to be an easier way out. In the first step away from set-valued $T_c$ we have the possibility of they being instead categories. In that case the higher homotopy conditions is that we should have a pseudofunctor $\Delta/F \to \mathcal{C}\mathrm{at}$. Even they are somewhat unpleasant and it is much better to pass to the associated fibred category $\mathcal{T} \to \Delta/F$. In the general case, and admitting that $\Delta/F$ is essentially the same things as $F$ itself, we should therefore look at (Serre) fibrations $X \to |F|$ or if we want to stay completely simplicial, Kan fibrations $X \to F$. This gives another notion of (very flabby) sheaf which now should be homotopy invariant (though that should probably be in the sense of homotopy equivalence of $\Delta$-enriched categories).
Torsten Ekedahl
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