It is known (see this other answerthis other answer) that an 8x8 board in which squares at opposite corners have been removed cannot be tiled with dominoes, as the removed squares are of the same "colour". But what if two squares of different colours are removed? Ralph E. Gomory showed that it is always possible, no matter where the two removed squares are, and this is his proof:
(Imagine A and B are the squares removed.) The image is from Mathematical Gems I by Ross Honsberger.