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May 4, 2014 at 21:39 comment added Will Sawin Your reduction to finding an independent set in some graph is an equivalence - a set satisfies $(X+X ) \cap S = \emptyset$ if and only if it is an independent set in your graph. So the optimal solution is the maximum independent set. If $|S|=1$, your graph is a union of disjoint edges, so a set is maximal independent if and only if it comes from your construction. Because the size of this set does not depend on $S$ as long as $|S|=1$, this is also the best possible among all sets with $X+X \neq (\mathbb Z/2)^n$.
May 4, 2014 at 6:16 comment added Seva @Will Sawin: do not get it; could you expand?
May 3, 2014 at 20:51 comment added Will Sawin This construction doubles as a proof of optimality, at least for $|S|=1$.
May 3, 2014 at 6:49 history edited Seva CC BY-SA 3.0
added 40 characters in body
May 3, 2014 at 6:16 history answered Seva CC BY-SA 3.0