CW since some of the recent posts on MO have required little more than googling.
Prior to the book you mentioned, MacLane attributed this saying to Peter Freyd in:
MacLane, S. (1965). Categorical algebra. Bulletin of the American Mathematical Society, 71(1), 40-106.
Relevant excerpt: (p. 48)
The only citation of Freyd in that piece (P. FreydWith regard to the original language, Eric Wofsey points out that Freyd's Relative homological algebra made absolute, Proc. Nat. Acad. Sci. U.S.A. 49Abelian Categories (1963), 19-201964) does not appear to be the source ofbegins with this quotation (if you can call it that) so the true origin may have to remain unknown.description: