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Regarding vanishing rational Pontryagin classes (which do vanish for conformally flat manifolds):

1. Recent result of Ontaneda gives examples in each dimension $\ge 4$ of closed manifolds with nonzero rational Pontryagin classes that are pinched arbitrary close to $-1$, see Corollary 4 of his paper "Pinched smooth hyperbolization" [arXiv:1110.6374].

2. On the other hand, if you restrict topology of your negatively pinched $n$-manifolds in a suitable way, then one can prove vanishing of Pontryagin classes for pinching close enough to $-1$. For example, for closed manifolds of uniformly bounded simplicial volume, if the pinching is close enough to $-1$, the manifold is diffeomorphic to a hyperbolic one (this is due to Gromov), and hence has zero Pontryagin classes. Long ago I proved similar results in the noncompact case, e.g. if you fix the fundamental group, and the dimension, and assume the metric is complete and the fundamental group is hyperbolic, then the Pontryagin classes vanish for pinching close to $-1$, see my paper Pinching, Pontrjagin classes, and negatively curved vector bundles. (I should mention that my proof depends on an accessibility result of Delzant-Potyagailo in which a gap was recently discovered by Louder-Touikan who announced a fix for hyperbolic groups, see Larsen Louder's Research Statement. Without the fix I can only handle the case of hyperbolic groups that do not split over {1} ot $\mathbb Z$.).

Regarding vanishing rational Pontryagin classes (which do vanish for conformally flat manifolds):

1. Recent result of Ontaneda gives examples in each dimension $\ge 4$ of closed manifolds with nonzero rational Pontryagin classes that are pinched arbitrary close to $-1$, see Corollary 4 of his paper "Pinched smooth hyperbolization" [arXiv:1110.6374].

2. On the other hand, if you restrict topology of your negatively pinched $n$-manifolds in a suitable way, then one can prove vanishing of Pontryagin classes for pinching close enough to $-1$. For example, for closed manifolds of uniformly bounded simplicial volume, if the pinching is close enough to $-1$, the manifold is diffeomorphic to a hyperbolic one (this is due to Gromov), and hence has zero Pontryagin classes. Long ago I proved similar results in the noncompact case, e.g. if you fix the fundamental group, and the dimension, and assume the metric is complete and the fundamental group is hyperbolic, then the Pontryagin classes vanish for pinching close to $-1$, see my paper Pinching, Pontrjagin classes, and negatively curved vector bundles. (I should mention that my proof depends on an accessibility result of Delzant-Potyagailo in which a gap was recently discovered by Louder-Touikan who announced a fix for hyperbolic groups, see Larsen Louder's Research Statement. Without the fix I can only handle the case of hyperbolic groups that do not split over {1} ot $\mathbb Z$.).

Regarding vanishing rational Pontryagin classes (which do vanish for conformally flat manifolds):

1. Recent result of Ontaneda gives examples in each dimension $\ge 4$ of closed manifolds with nonzero rational Pontryagin classes that are pinched arbitrary close to $-1$, see Corollary 4 of his paper "Pinched smooth hyperbolization".

2. On the other hand, if you restrict topology of your negatively pinched $n$-manifolds in a suitable way, then one can prove vanishing of Pontryagin classes for pinching close enough to $-1$. For example, for closed manifolds of uniformly bounded simplicial volume, if the pinching is close enough to $-1$, the manifold is diffeomorphic to a hyperbolic one (this is due to Gromov), and hence has zero Pontryagin classes. Long ago I proved similar results in the noncompact case, e.g. if you fix the fundamental group, and the dimension, and assume the metric is complete and the fundamental group is hyperbolic, then the Pontryagin classes vanish for pinching close to $-1$, see here. (I should mention that my proof depends on an accessibility result of Delzant-Potyagailo in which a gap was recently discovered by Louder-Touikan who announced a fix for hyperbolic groups, see here. Without the fix I can only handle the case of hyperbolic groups that do not split over {1} ot $\mathbb Z$.).

Regarding vanishing rational Pontryagin classes (which do vanish for conformally flat manifolds):

1. Recent result of Ontaneda gives examples in each dimension $\ge 4$ of closed manifolds with nonzero rational Pontryagin classes that are pinched arbitrary close to $-1$, see Corollary 4 of his paper "Pinched smooth hyperbolization" [arXiv:1110.6374].

2. On the other hand, if you restrict topology of your negatively pinched $n$-manifolds in a suitable way, then one can prove vanishing of Pontryagin classes for pinching close enough to $-1$. For example, for closed manifolds of uniformly bounded simplicial volume, if the pinching is close enough to $-1$, the manifold is diffeomorphic to a hyperbolic one (this is due to Gromov), and hence has zero Pontryagin classes. Long ago I proved similar results in the noncompact case, e.g. if you fix the fundamental group, and the dimension, and assume the metric is complete and the fundamental group is hyperbolic, then the Pontryagin classes vanish for pinching close to $-1$, see my paper Pinching, Pontrjagin classes, and negatively curved vector bundles. (I should mention that my proof depends on an accessibility result of Delzant-Potyagailo in which a gap was recently discovered by Louder-Touikan who announced a fix for hyperbolic groups, see Larsen Louder's Research Statement. Without the fix I can only handle the case of hyperbolic groups that do not split over {1} ot $\mathbb Z$.).

Regarding vanishing Pontryagin classes:

1. Recent result of Ontaneda gives examples in each dimension $\ge 4$ of closed manifolds with nonzero rational Pontryagin classes that are pinched arbitrary close to $-1$, see Corollary 4 of his paper "Pinched smooth hyperbolization".

2. On the other hand, if you restrict topology of your negatively pinched $n$-manifolds in a suitable way, then one can prove vanishing of Pontryagin classes for pinching close enough to $-1$. For example, for closed manifolds of uniformly bounded simplicial volume, if the pinching is close enough to $-1$, the manifold is diffeomorphic to a hyperbolic one (this is due to Gromov), and hence has zero Pontryagin classes. Long ago I proved similar results in the noncompact case, e.g. if you fix the fundamental group, and the dimension, and assume the metric is complete and the fundamental group is hyperbolic, then the Pontryagin classes vanish for pinching close to $-1$, see here. (I should mention that my proof depends on an accessibility result of Delzant-Potyagailo in which a gap was recently discovered by Louder-Touikan who announced a fix for hyperbolic groups, see here. Without the fix I can only handle the case of hyperbolic groups that do not split over {1} ot $\mathbb Z$.).

Regarding vanishing rational Pontryagin classes (which do vanish for conformally flat manifolds):

1. Recent result of Ontaneda gives examples in each dimension $\ge 4$ of closed manifolds with nonzero rational Pontryagin classes that are pinched arbitrary close to $-1$, see Corollary 4 of his paper "Pinched smooth hyperbolization".

2. On the other hand, if you restrict topology of your negatively pinched $n$-manifolds in a suitable way, then one can prove vanishing of Pontryagin classes for pinching close enough to $-1$. For example, for closed manifolds of uniformly bounded simplicial volume, if the pinching is close enough to $-1$, the manifold is diffeomorphic to a hyperbolic one (this is due to Gromov), and hence has zero Pontryagin classes. Long ago I proved similar results in the noncompact case, e.g. if you fix the fundamental group, and the dimension, and assume the metric is complete and the fundamental group is hyperbolic, then the Pontryagin classes vanish for pinching close to $-1$, see here. (I should mention that my proof depends on an accessibility result of Delzant-Potyagailo in which a gap was recently discovered by Louder-Touikan who announced a fix for hyperbolic groups, see here. Without the fix I can only handle the case of hyperbolic groups that do not split over {1} ot $\mathbb Z$.).