The irrationality of Catalan's constantCatalan's constant $G=1-1/3^2+1/5^2-1/7^2+\cdots$.
Remarks: Although Catalan's constant is certainly well-known, the irrationality is the tip of the iceberg of a related conjecture of Milnorconjecture of Milnor about the linear independence over the rationals of volumes of certain hyperbolic 3-manifolds (which is a special case of a conjecture of Ramakrishnan). The irrationality of Catalan's constant would imply that the volume of the unique hyperbolic structure on the Whitehead link complement is irrational. To this date, it is not known that any hyperbolic 3-manifold has irrational volume.