Let $P$ be a convex polytope in $\mathbb{R}^3$ whose every vertex lies in the $\mathbb{Z}^3$ lattice.
Question: If $P$ contains exactly one lattice point in its interior, what is the maximum possible volume of $P$?
Notice that a convex lattice polytope with no interior lattice point can have arbitrarily large volume, but if the number of interior lattice points in it is a given finite number, then its volume cannot be arbitrarily large. In two dimensions the answer is known: A convex lattice polygon with exactly one interior point has volume at most $9/2$, which follows from a more general inequality by P.R. Scott (see On Convex Lattice Polygons, Bull. Austral. Math. Soc., vol 15; 1976, 395-399).
The best example I know in that respect is the tetrahedron with vertices $(0,0,0),\ (4,0,0),\ (0,4,0)$ and $(0,0,4)$, with volume ${32}\over3$. Is this perhaps the maximum volume? Of course, the same question can be asked in higher dimensions as well, with an analogous example to consider as a possible candidate for an answer.
In view of several examples presented in answers and comments below, it seems that the optimal polytope should be a simplex, in every dimension. Has this been conjectured already?