When $M$ is a compact $2$-manifold, with or without boundary, $P(M)$ is known. When $M$ is a 3-manifold there's bits and pieces known, especially once you get to more fine detail like pseudo-isotopy embedding spaces. But at the level of $P(M)$ I don't think there's a complete description for a single $3$-manifold. For $4$-manifolds the situation is worse, but again there are some things known for pseudo-isotopy embedding spaces.
edit 2: Rick Litherland generalized a result of Zeeman (Deforming twist-spun knots TAMS 250 (1979) 311--331) showing that "Deform-spun knots" have complements that frequently fibre over $S^1$. This process called "Deform spinning" is just the boundary map in the pseudo-isotopy fibre sequence for spaces of knots. One of the nice things about this is Litherland gives a prescription for what the fibre is. In the case where you're looking at the pseudo-isotopy sequence for long knots in $\mathbb R^3$, it generates long embeddings of $\mathbb R^2$ in $\mathbb R^4$. So the fibre is a 3-manifold with boundary a sphere. This process produced some embeddings of 3-manifolds in the 4-sphere that nobody had known about at the time, like the once-punctured Poincare Dodecahedral Space (which without a puncture does not embed in $\mathbb R^4$, at least, not smoothly, it does admit a tame topological embedding). I got interested in this case largely because it represents sort of an extreme end of the terrain of your dissertation.
edit 3: I forgot to mention, I kept on pushing trying to understand why your dissertation broke down in co-dimension two. In some sense my paper "An obstruction to a knot being deform-spun via Alexander polynomials" is an answer. In a way it's not, since co-dimension two deform-spinning is more of a free loop space construction than a based loop space construction. But I found the exercise informative.