Here is a problem that I learned from W. Thurston. I do not remember whose problem it was originally. Possibly Conway?
Suppose that you have a finite collection of round circles in round $S^3$, not necessarily all of the same radius, such that each pair is linked exactly once. (In particular, no two intersect.) Prove that there is an isotopy in the space of such collections of circles so that afterwards, they are all great circles.