From a post to The Jouanolou trick:
Are all topologically trivial (contractible) complex algebraic varieties other then affine lines necessarily affine? Are all there examples of them rationalthose not birationally equivalent to an affine space?
The examples that come to my mind are like similar to a singular $\mathbb P^1$ without a point given by equation $x^2 = y^3$. This particular curve is also clearly birationally equivalent to affine line.
Perhaps the affine "affine" part would follow follows from a comparison between Zariski cohomology and complex cohomology?

