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# Determinant of block matrix

I have a 4n$\times$4n matrix, which can be written as \begin{pmatrix} 0 & A &B &C \cr D& 0& E & F \cr G& H & 0 & J \cr K& L& M& 0 \end{pmatrix}

each entry being an n$\times$n matrix with vanishing determinant. Is there a rule for checking if the full matrix has zero determinant? How about the special case \begin{pmatrix} 0 & A &B &C \cr -A^T & 0& E & F \cr -B^T & E^T & 0 & J \cr -C^T & F^T & J^T & 0 \end{pmatrix}

still with vanishing determinants for each n$\times$n matrix?

(The n is the dimension of an SU group -- I can probably work out the SU(2) or n=3 case by brute force, but I would like to know if there is some method that does not require explicit calculation.)

Many thanks in advance for any help or suggestion.