Edit David asked where a proof of this "positive" result could be found. I learned it from a Cambridge Part III problem sheet by Peter Johnstone, and it's probably out there somewhere in the literature (e.g. maybe in Johnstone's Sketches of an Elephant). But since consulting the literature means getting up from the couch, I'll type out a proof instead.
So, let $M = (M, \eta, \mu)$ be a monad on Set such that there exists at least one $M$-algebra with more than one element. Write $F: \mathrm{Set} \to \mathrm{Set}^M$ for the free algebra functor, and $U: \mathrm{Set}^M \to \mathrm{Set}$ for the underlying set functor; thus, $M = UF$.
First we show that $\eta: id \to M$ is monic. This means for each set $A$ and each $a, b \in A$ with $a \neq b$, we have $\eta_A(a) \neq \eta_A(b)$. By the universal property of $\eta_A$, this is equivalent to the assertion that for some $M$-algebra $X$ and map $f: A \to U(X)$ of sets, we have $f(a) \neq f(b)$. (I'd like to draw a commutative triangle to illustrate this.) Choose any $M$-algebra $X$ with more than one element: then such an $f$ can indeed be constructed.
Next we show that $F$ is faithful. It will follow that $M = UF$ is faithful, since $U$ (being monadic) is also faithful. Faithfulness of $F$ is in fact equivalent to each $\eta_A$ being monic, by general properties of adjunctions; I think that's in Categories for the Working Mathematician. Anyway, the proof is that if $f, g: A \to B$ are maps of sets with $Ff = Fg$ then $\overline{Ff} = \overline{Fg}$ (where the bar indicates transpose); but $\overline{Ff} = \eta_B \circ f: A \to UF(B)$ and similarly for $g$, and $\eta_B$ is monic, so $f = g$.
Finally we show that $F$ reflects isos. It will follows that $M = UF$ reflects isos, since $U$ (being monadic) also reflects isos. A faithful functor always reflects both epis and monos, and any map in Set that's both epi and mono is an iso. Hence any faithful functor out of Set reflects isos, and the result follows from the previous part.

