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It is a famous problem (due to Banach and Mazur) whether a separable infinite dimensional Banach space which has a transitive isometry group must be isometrically isomorphic to a Hilbert space. Of course, if every two dimensional subspace has a transitive isometry group, then the space is a Hilbert space since then the norm satisfies the parallelogram identity. For counterexamples in the non separable setting, consider the $\ell_p$ sum of uncountably many copies of $L_p(0,1)$ with $p$ not $2$.
It is a famous problem whether a separable infinite dimensional Banach space which has a transitive isometry group must be isometrically isomorphic to a Hilbert space. Of course, if every two dimensional subspace has a transitive isometry group, then the space is a Hilbert space since then the norm satisfies the parallelogram identity. For counterexamples in the non separable setting, consider the $\ell_p$ sum of uncountably many copies of $L_p(0,1)$ with $p$ not $2$.