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Yes, it generalizes.

For any two (nondegenerate) nondegenerate tetrahedra A and B, you can find an affine transformation such that T(A)=B. Since affine transformations preserve ratios of line segments and areas and volumes, with a Routh's-theorem-type construction the ratio of volumes volume of outer : original tetrahedron to volume of inner tetrahedra polyhedron will be preserved.

As a commenter pointed out, with a tetrahedron there may be more than one way of defining a sensible cut. Once you've defined this, though, you can find a convenient tetrahedron (maybe a regular one, maybe one with a lot of right angles) and use it to calculate the proportion you want.

1

Yes, it generalizes.

For any two (nondegenerate) tetrahedra A and B, you can find an affine transformation such that T(A)=B. Since affine transformations preserve ratios of line segments and areas and volumes, with a Routh's-theorem-type construction the ratio of volumes of outer : inner tetrahedra will be preserved.

As a commenter pointed out, with a tetrahedron there may be more than one way of defining a sensible cut. Once you've defined this, though, you can find a convenient tetrahedron (maybe a regular one, maybe one with a lot of right angles) and use it to calculate the proportion you want.