I am surprised that this one did not already occurred : Perelman's proof of the Poincaré conjecture.
Endow a simply connected three-manifold with any Riemannian metric. Let the metric evolve under the Ricci flow. When singularities occur, cut them out and smoothly glue a cap in the hole, checking that the topology has not changed. After some time, you get a round metric so your manifold is a sphere.