Well, a representative example is where you take some arbitrary etale cover Y of X which splits over a closed subvariety Z of X, then form the Nisnevich cover of X consisting of the open complement X - Z together with the open subscheme Y' of Y where you remove all but one of the copies of Z lying above Z. For instance Z could be a point, and our field could be algebraically closed.
The intuition I find helpful is that descent for the Nisnevich topology is meant to be an easier-to-precisely-phrase consequence of the principle "X is gotten by gluing X-Z to a tubular neighborhood of Z, along the punctured tubular neighborhood of Z". The idea being that, in the situation of the previous paragraph, the tubular neighborhoods of Z in X and Z in Y should be the same, Y --> X being etale.
As an example of this intuition, note that if X is a smooth variety of dimension n (over an algebraically closed field for simplicity) and x is a point of X, then by choosing n independent parameters at x you can find a Zariski neighborhood X' of x and an etale map X' --> A^n which, together with A^n - 0 ---> A^n, makes a Zariski Nisnevich cover of A^n with intersection equal to X'-x. This corresponds (ish) to the fact that the tubular neighborhood of x in X should be the same as the tubular neighborhood of 0 in A^n.
