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Is it true that there are exactly two conjugacy classes of order two elements in Out(R)?

In the title, $R$ stands for the hyperfinite III1 factor. An order two element $\alpha\in Out(M)$ ($M$ any factor) has an invariant $c(\alpha)\in H^3(\mathbb Z/2,S^1)=\mathbb Z/2$. Q: Is $c$ the ...