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Path connected set of matrices?

Consider the collection of $n$ by $n$ matrices $$S=\{ A: A_{ij}\le0,\quad (-1)^{c_i}\det A(P_i;Q_i)<0 \quad \text{for} \quad i=1,\ldots, k\}$$ where $c_i\in \{0,1\}$, $P_i$ and $Q_i$ are disjoint ...