We can prove something stronger, that there is no path at all. (That is removing the Hamiltonian condition) What follows is a proof for sufficiently large $n$. The proof makes use of the prime number theorem, a corollary of the Selberg sieve, and a result concerning prime gaps.

*Proof:* We proceed by contradiction.

**$n$ odd:** If $n=2k+1$, then we may color the board as a checkerboard. Note that odd squares will always be the same color, and even squares will always be the same color. Since the knight alternates colors on each jump, and there is only one even prime, the result follows.

**$n$ even:** If $n=2k$, we similarly color the odd squares white, and the even squares black. Ignore the prime 2, so that all primes we are dealing with are odd. This means that if we are on a white square, we must jump to a white square. If we are on the first row, this tells us that the knights next move *must* be a jump to the second row, either two to the left, or two to the right.

*Key Idea:* Since we must jump from the first row to the second, this means if we can avoid double counting, there are at least the same number of primes in the second row as in the first. However, the second row contains larger numbers, and the density of the primes decreases as we go to infinity. In particular, if $x<n$, the density of the primes in the interval $[n+1,n+x]$ will be smaller then the density of the primes in $[1,x]$. Since $[n+1,n+x]$ is in the second row, and $[1,x]$ is in the first row, this contradicts the fact that the second row should have more primes.

Consider the set $\mathcal{P}_x$ to be the set primes less then $x$ where we have thrown out all pairs of primes $p,p+2\in \mathcal{P}$ and $p,p+4\in \mathcal{P}$. We throw out these pairs to avoid double counting. By using the Selberg sieve results, we know that are $\ll \frac{x}{\log^2 x}$ such pairs, and so it follows that $$|\mathcal{P}_x| \sim \frac{x}{\log x}$$ as $x\rightarrow \infty$. Now, choose $x\leq n$ so that all the elements of $\mathcal{P}_x$ lie in the first row. Assuming the path exists, we must have a prime in the second row within jumping distance for each prime in the first row. By the condition that we have no pairs of the form $p,p+2$, or $p,p+4$ in our set, we see that among the integers $[n,n+x]$ we must have at least $|\mathcal{P}_x|$ primes. (The condition regarding prime pairs makes sure that no prime in the second row is used as the jumping point for two distinct primes in the first row.) Heath-Brown showed that $$\pi(n+n^{7/12})-\pi(n)\sim \frac{n^{7/12}}{\log n},$$ (we can use a weaker result then this) so taking $x=n^{7/12}$ we see there are $\frac{n^{7/12}}{\log n}$ primes in the interval $[n,n+x]$. However, we had bounded this quantity below by $|\mathcal{P}_x|\sim \frac{n^{7/12}}{\log n^{7/12}}$, and this gives the asymptotic inequality $$\frac{n^{7/12}}{\log n} \gtrsim \frac{12}{7} \frac{n^{7/12}}{\log n},$$ which is evidently false.

**Remark:** We need only $$\pi(x+x^{\theta})-\pi(x)\sim \frac{x^\theta}{\log x}$$ for some $\theta<1$, $\theta=\frac{7}{12}$ is much stronger than what is required.

**Remark 2:** If we wanted only to prove the conjecture for Hamiltonian paths, we did not need to spend time removing the twin primes pairs for fear of double counting, since a Hamiltonian path by definition implies we cannot double count.

**Remark 3:** It is quite likely that there is a clever elementary approach to solving the problem when $n$ is even.