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Let $F,G:C\to D$ be naturally isomorphic functors. Taking the nerve, is $NF,NG:NC\to ND$ homotopy equivalent? Conversely, given a simplicial map $f:NC\to ND$, does there exists a functor $F:C\to D$ such that $NF=f$?

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Just one comment. The homotopy class of f may be realized by non-equivalent functors $C\rightarrow D$. – Fernando Muro Dec 14 '11 at 7:45
... unless $D$ is a groupoid. – Fernando Muro Dec 14 '11 at 7:46
@Gao 2Man: Although this is an interesting question, it can be answered just using the definitions. You should tell us what you have tried so far. See also – Martin Brandenburg Dec 14 '11 at 11:38
As Fernando notes, the content of your title is different from the content of your question: in particular the functor is not full... you cannot recover the category from the homotopy type of its nerve, in general. However, if you take Rezk's version of the nerve to get a bisimplicial set, the homotopy type of this remembers the original category. – Dylan Wilson Dec 14 '11 at 16:02
up vote 4 down vote accepted

Yes to both. A natural transformation is a functor $C\times 2 \to D$, the nerve preserves products, and the nerve of $2$ is the 1-simplex. Geometric realisation gives homotopic maps. The second is elementary by the definition of nerve.

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