Let $X$ be a compact complex manifold. By definition, $Pic(X)={\rm H^1}(X,\mathcal{O}^\times)$. We know a lot about this group. What is known about the groups ${\rm H^n}(X,\mathcal{O}^\times)$ for $n\ge 2$?

A bit more specialized question. It is well known that for a nonsingular projective complex variety $X$ the natural map $${\rm H^1}(X,\mathcal{O}^\times)\to{\rm H^1}(X,\mathcal{M}^\times)$$ is trivial. What is known about the kernel of the same map for $n=2$ or $n=3$? (Here $\mathcal{M}^\times$ is the sheaf of nonzero meromorphic functions, and the topology is the strong one).