It actually remains hard, although not as hard. See the paper Hardness of approximating the closest vector problem with pre-processing by Alekhnovich, Khot, Kindler, and Vishnoi (FOCS 2005, http://www.math.ias.edu/~misha/papers/cvpp.pdf). They show that even if you are allowed to do arbitrary pre-processing after having been given the lattice basis but before seeing the target vector, you still can't get a better approximation factor than $(\log n)^{1/2-\varepsilon}$, assuming your calculations after seeing the target vector must run in polynomial time, and assuming that there are no quasi-polynomial-time algorithms for NP.
However, you do get real benefit from being able to do lattice basis reduction in advance (not just LLL reduction, but something more computationally intensive). For example, Lagarias, Lenstra, and Schnorr showed that using Korkine-Zolotarev reduction, you could get an $n^{1.5}$ approximation factor (Combinatorica 10 (1990), 333–348). In FOCS 2004, Aharonov and Regev got a $\sqrt{n/\log n}$ approximation factor with pre-processing. However, in all these algorithms the pre-processing requires more than polynomial time.