Recently, Richard Dore asked us if $\mathbb R^3$ is the cartesian square of some space, and Tyler Lawson answered beautifully in the negative.
The even powers of $\mathbb R$ were left out in that question because, well, it is obvious that they are squares. Now:
Are they squares in a unique way? In other words, if a space $X$ is such that $X\times X\cong\mathbb R^{2n}$, must $X$ be homeomorphic to $\mathbb R^n$?
One can consider other values of $2$ in Richard's question or here, as well as look for factors instead of only square roots (but if I recall correctly $\mathbb R^5$ has all exotic $\mathbb R^4$s as factors, so the last variant might be «trivial»...)