I wrote this up for my own personal edification when I was going through Gompf and Stipsicz. Please, excuse the pedantry. I had to make sure even I understood it.

**Definition:** (**Smoothly Slice Knot**)
A knot $K$ in $\partial D^4$, where $D^n$ is the standard closed $n$--dimensional disk, is smoothly slice if there exists a two-disk $D^2$ smoothly embedded in $D^4$ such that the image of $\partial D^2$ is $K$.

**Definition:** (**Flat Topological Embedding**)
Let $X$ be a topological manifold of dimension $n$ and $Y$ a topological manifold of dimension $m$ where $n < m$. A topological embedding $\rho : X \rightarrow Y$ is flat if it extends to a topological embedding $\rho : X \times D^{m - n} \rightarrow Y$.

**Definition:** (**Topologically Slice Knot**)
A knot $K$ in $\partial D^4$ is topologically slice if there exists a two-disk $D^2$ flatly topologically embedded in $D^4$ such that the image of $\partial D^2$ is $K$.

**Lemma 1:**
Let $K$ be a knot in $\partial D^4$ and $X_K$ the two-handlebody obtained by attaching a two-handle to $D^4$ along $K$ with framing $0$. $X_K$ has a smooth embedding into $\mathbb{R}^4$ iff $K$ is smoothly slice.

**Proof:**
First, let us assume there exists a smooth embedding $\rho: X_K \rightarrow \mathbb{R}^4$ and prove $K$ is smoothly slice.

As $X_K$ is compact and $\rho$ a smooth embedding, $\rho(X_K)$ is compact. Thus, the Heine-–Borel Theorem (Theorem 2.41) Rudin implies there exists an open ball $B^4 \subset \mathbb{R}^4$ such that $\rho(X_K) \subset B^4$. Therefore, $\rho$ can be used to create a smooth embedding $\rho: X_K \rightarrow S^4$, mapping $X_K$ to one hemisphere.

The zero-handle of $X_K$ is $D^4$. Thus, $\rho$ smoothly embeds this $D^4$ into $S^4$. The Disk Theorem (Corollary 4.7 Chapter III) Kosinski implies that any two orientation preserving smooth embeddings of $D^4$ into $S^4$ are isotopic. Thus, the closure of the complement of any open ball in $S^4$ is diffeomorphic to $D^4$. Hence, $S^4 - int(\rho(D^4))$ is diffeomorphic to $D^4$, where $int(X)$ denotes the interior of $X$.

By construction, $K$ is smoothly embedded in $\partial(S^4 - int(\rho(D^4)))$ and the $D^2$ core of the $X_K$ two-handle is smoothly embedded in $S^4 - int(\rho(D^4))$ such that the image of $\partial D^2$ is $K$. Thus, we conclude that if there exists a smooth embedding $\rho: X_K \rightarrow \mathbb{R}^4$, then $K$ is smoothly slice.

Now, let us assume $K$ is smoothly slice and prove there exists a smooth embedding $\rho': X_K \rightarrow \mathbb{R}^4$.

We now work backwards. As $K$ is smoothly slice, there exists a smooth embedding of $D^2$ into $D^4$ such that the image of $\partial D^2$ is $K$. As this $D^2$ is smoothly embedded, the Tubular Neighborhood Theorem (Theorem 4.2 Chapter III) Kosinski implies there exists a closed tubular neighborhood $D^2 \times D^2$ of $D^2$ smoothly embedded in $D^4$. (This closed tubular neighborhood will become the two-handle of $X_K$.)

Using the identity map glue a second $D^4$ to the above $D^4$ forming $S^4$ as $D^4 \cup_{\partial D^4} \bar{D}^4$, where $\bar{D}^4$ is $D^4$ with the opposite orientation. This new $D^4$ along with the closed tubular neighborhood above forms $X_K$. This two-handlebody $X_K$ is smoothly embedded into $S^4$. We notate this smooth embedding as $\rho'$.

We can modify the closed tubular neighborhood above, shrinking it if required, such that $S^4 - \rho'(X_K)$ is not empty. Thus, removing a point in $S^4 - \rho'(X_K)$ we obtain the desired smooth embedding $\rho': X_K \rightarrow \mathbb{R}^4$. **QED**.

**Lemma 2:**
Let $K$ be a knot in $\partial D^4$ and $X_K$ the two-handlebody obtained by attaching a two-handle to $D^4$ along $K$ with framing $0$. $X_K$ has a topological embedding into $\mathbb{R}^4$ iff $K$ is topologically slice.

**Proof:**
First, let us assume there exists a topological embedding $\rho: X_K \rightarrow \mathbb{R}^4$ and prove $K$ is topologically slice.

A slight variation of the logic in the previous proof implies $\rho$ can be used to create a topological embedding $\rho: X_K \rightarrow S^4$, mapping $X_K$ to one hemisphere.

Again, a variation of the logic in the previous proof implies that $D^4$ is diffeomorphic to $S^4 - int(\rho(D^4))$, where $\rho$ is acting on $D^4$ the zero-handle of $X_K$.

By construction, $K$ is topologically embedded in $\partial(S^4 - int(\rho(D^4)))$, and $D^2$, the core of the $X_K$ two-handle, is topologically embedded in $S^4 - int(\rho(D^4))$ such that the image of $\partial D^2$ is $K$.

The two-handle of $X_K$, which is homeomorphic to $D^2 \times D^2$, is topologically embedded into $S^4 - int(\rho(D^4))$ such that it extends the topological embedding of $D^2$, the core of the $X_K$ two-handle. Thus, we conclude that if there exists a topological embedding $\rho: X_K \rightarrow \mathbb{R}^4$, then $K$ is topologically slice.

Now, let us assume $K$ is topologically slice and prove there exists a topological embedding $\rho': X_K \rightarrow \mathbb{R}^4$.

Again, we work backwards. As $K$ is topologically slice, there exists a topological embedding of $D^2$ into $D^4$ such that the image of $\partial D^2$ is $K$ and there exists a topological embedding of $D^2 \times D^2$ into $D^4$ that extends the topological embedding of $D^2$. (This topological embedding of $D^2 \times D^2$ will become the two-handle of $X_K$.)

Using the identity map glue a second $D^4$ to the above $D^4$ forming $S^4$ as $D^4 \cup_{\partial D^4} \bar{D}^4$. This new $D^4$ along with the above topological embedding of $D^2 \times D^2$ forms $X_K$. This two-handlebody $X_K$ is topologically embedded into $S^4$. We notate this topological embedding as $\rho'$.

Using the same logic as in the previous proof, we can remove a point from $S^4 - \rho'(X_K)$ to construct the desired topological embedding $\rho': X_K \rightarrow \mathbb{R}^4$. **QED**.

**Definition:** (**Large Exotic $\mathbb{R}^4$**)
A large exotic $\mathbb{R}^4$ is an exotic $\mathbb{R}^4$ containing a four-dimensional compact smooth submanifold that can not be smoothly embedded into $\mathbb{R}^4$.

**Thorem:**
If there exists a knot $K$ that is topologically slice but not smoothly slice, then there exists a large exotic $\mathbb{R}^4$.

**Proof:**
As $K$ is topologically slice, Lemma 2 implies there exists $\rho$ a topological embedding of $X_K$ into $\mathbb{R}^4$, where $X_K$ is the two-handlebody obtained by attaching a two-handle to $D^4$ along $K$ with framing $0$.

First let us prove $\mathbb{R}^4 - int(\rho(X_K))$ is a topological manifold. As $\rho$ is a topological embedding, $\rho(X_K)$ is a topological submanifold of $\mathbb{R}^4$. Hence, $int(\rho(X_K))$ is also a topological submanifold of $\mathbb{R}^4$. This implies $\mathbb{R}^4 - int(\rho(X_K))$ is a topological submanifold of $\mathbb{R}^4$. Thus, $\mathbb{R}^4 - int(\rho(X_K))$ is a topological manifold in its own right.

Next let us prove $\mathbb{R}^4 - int(\rho(X_K))$ is not compact. $X_K$, by construction, is compact. Thus, as $\rho$ is a topological embedding, $\rho(X_K)$ is a compact topological submanifold of $\mathbb{R}^4$. As $\mathbb{R}^4$ is not compact, it follows that $\mathbb{R}^4 - \rho(X_K)$ is not compact. Hence, as $\mathbb{R}^4 - \rho(X_K)$ has two ends, this implies $\mathbb{R}^4 - int(\rho(X_K))$ is not compact.

Now we will prove $\mathbb{R}^4 - int(\rho(X_K))$ is connected. In the standard handle presentation, $S^4$ has no one-handles. Thus, as a result of Theorem 3.4 Chapter VII Kosinski, we have $H_1(S^4;\mathbb{Z}) = 0$. As in Lemma 2, we can use $\rho$ to create a topological embedding $\rho: X_K \rightarrow S^4$. Hence, $\rho(X_K)$ is a closed, proper subset of the compact connected orientable manifold $S^4$. Thus, Alexander Duality (Theorem 6.6(a) Chapter XIV) Massey implies that the Cech cohomology group $\check{H}^3(\rho(X_K);\mathbb{Z})$ is isomorphic to reduced homology group $\tilde{H}_0(S^4 - \rho(X_K);\mathbb{Z})$. As $X_K$ is compact, $\rho(X_K)$ is compact. Thus, $\rho(X_K)$ is paracompact. Hence, (Page 372) Massey $\check{H}^3(\rho(X_K);\mathbb{Z})$ is isomorphic to $H^3(\rho(X_K);\mathbb{Z})$. As $\rho$ is a topological embedding, $H^3(\rho(X_K);\mathbb{Z})$ is isomorphic to $H^3(X_K;\mathbb{Z})$. The ``lower'' boundary $\partial_- X_K$ of $X_K$ is empty. Thus, $H^3(X_K;\mathbb{Z})$ is isomorphic to $H^3(X_K,\partial_- X_K;\mathbb{Z})$. Poincare duality (Theorem 5.1 Chapter VII) Kosinski then implies $H^3(X_K,\partial_- X_K;\mathbb{Z})$ is isomorphic to $H_1(X_K,\partial_+ X_K;\mathbb{Z})$. However, as $X_K$ has no three-handles, Theorem 3.4 Chapter VII Kosinski implies $H_1(X_K,\partial_+ X_K;\mathbb{Z}) = 0$. Thus, tracing isomorphisms, we have proven $\tilde{H}_0(S^4 - \rho(X_K);\mathbb{Z}) = 0$; in other words $S^4 - \rho(X_K)$ is connected. Removing a point from a four-manifold will not disconnect it; thus, $\mathbb{R}^4 - \rho(X_K)$ is connected. (Equivalently, one could prove this by applying Alexander Duality again.) Finally, as adding in boundary points also does not disconnect, $\mathbb{R}^4 - int(\rho(X_K))$ is also connected.

So, as $\mathbb{R}^4 - int(\rho(X_K))$ is a non-compact connected topological four--manifold, Theorem 9.4.22 Gompf and Stipsicz implies $\mathbb{R}^4 - int(\rho(X_K))$ admits a smooth structure.

As $\rho$ is a topological embedding, the restriction $\rho: \partial X_K \rightarrow \partial (\mathbb{R}^4 - int(\rho(X_K)))$ is a homeomorphism. Thus, $\partial X_K$ and $\partial (\mathbb{R}^4 - int(\rho(X_K)))$ are homeomorphic.

As $X_K$ is a smooth manifold, it induces a smooth structure on $\partial X_K$. Similarly, as $\mathbb{R}^4 - int(\rho(X_K))$ is a smooth manifold, it induces a smooth structure on $\partial (\mathbb{R}^4 - int(\rho(X_K)))$. A topological three-manifold admits a unique smooth structure Moise. Thus, the smooth structure on $\partial X_K$ is the same as that on $\partial (\mathbb{R}^4 - int(\rho(X_K)))$. Hence, $\partial X_K$ and $\partial (\mathbb{R}^4 - int(\rho(X_K)))$ are diffeomorphic.

The diffeomorphism of $\partial X_K$ and $\partial (\mathbb{R}^4 - int(\rho(X_K)))$ can be used to join $X_K$ and $\mathbb{R}^4 - int(\rho(X_K))$ along their respective boundaries forming a smooth manifold $R$. Obviously, $R$ is homeomorphic to $\mathbb{R}^4$.

We will now prove, by contradiction, that $R$ is exotic. Let us assume $R$ is diffeomorphic to $\mathbb{R}^4$. Thus, there exists a diffeomorphism $\varphi: R \rightarrow \mathbb{R}^4$. The restriction of this diffeomorphism to $X_K$, which is smoothly embedded in $R$, is a smooth embedding of $X_K$ into $\mathbb{R}^4$. However, Lemma 1 implies such a smooth embedding exists if and only if $K$ is smoothly slice. But, by hypothesis, $K$ is not smoothly slice. Thus, our assumption that there exists a diffeomorphism $\varphi: R \rightarrow \mathbb{R}^4$ leads to a contradiction. Therefore, no such diffeomorphism exists. Hence, $R$ is exotic, homeomorphic but not diffeomorphic to $\mathbb{R}^4$.

Finally, we prove $R$ is large. $X_K$, by construction, is compact. Also, by construction, $X_K$ is a smooth submanifold of $R$, an exotic $\mathbb{R}^4$. By hypothesis, $K$ is not smoothly slice. Thus, Lemma 1 implies $X_K$ can not smoothly embed in $\mathbb{R}^4$. Hence, we conclude, $R$ is large. **QED**.