In pondering this MO question and people's efforts to answer it, and recalling also something that I learned in my youth about using Morse theory ideas to prove some results of Lefschetz in the complex case, I seem to have learned two things -- things that I suppose are absorbed in the cradle by those who study algebraic geometry as opposed to learning it by osmosis -- or maybe I haven't got them quite right. Anyway:

(1) Blowing up a surface at a smooth point does not change the fundamental group, and (therefore ?) the fundamental group of a smooth projective surface is a birational invariant.

(2) Surfaces in $\mathbb P^3$ are simply connected, and more generally for a set $X\subset\mathbb P^n$ defined by a single homogeneous equation of degree $>0$ the pair $(\mathbb P^n,X)$ is at least $(n-1)$-connected. That is, the relative homotopy groups and therefore the relative homology groups vanish up through dimension $n-1$.)

(This is all over the complex numbers.)

Is this correct? And, taking off from (1), what are some other simple statements about invariants from homotopy theory that are birational invariants? And what are the first things to know about birational invariants that do not come from topology?

EDIT I wish I could accept more than one answer.