It's a big, famous, hard problem in operator algebras to determine if the von Neumann algebras $L(F_2)$ and $L(F_3)$ are isomorphic, or not. Here $F_n$ is the free group on n generators and $L(F_n)$ is the weak-operator-topology closure of the group algebra $\mathbb C[F_n]$ acting naturally on the Hilbert space $\ell^2(F_n)$.

I presume it must be known if the algebras $\mathbb C[F_2]$ and $\mathbb C[F_3]$ are isomorphic or not. But from casually asking a few algebraists, I've never had any luck in finding this out (I admit to not working very hard on this!) I'm guessing some (co)homology theories must help...? What about for replacing $\mathbb C$ by a more general ring?