There are nice results for representing homology classes by submanifolds, in particular for any class in $H_i(X)$ with $i\le 6$, see here. When $X$ is low-dimensional I can start getting explicit, but this uses Poincare duality and appeals to classifying maps and characteristic classes of bundles. What is the right way to approach the problem for relative homology? Does the formulation of (Thom) spectra extend here? While I do have Lefschetz duality, I don't think I can do much with bundles, and I am not comfortable with (Thom) spectra.
Given a submanifold $A\subset X$ of a closed (smooth?) manifold, when can I (not) represent a homology class in $H_i(X,A;\mathbb{Z})$ by some submanifold with appropriate boundary?
Take whatever restrictions on $i$ and $\dim X$, but assume we're in a setting where the Hurewicz map isn't an isomorphism. If $i>\dim A+1$ then $H_i(X)$ surjects onto $H_i(X,A)$ in the LES, so we can take a submanifold which represents a homology class of $X$ to be the submanifold that represents the relative homology class.
Perhaps there is an example of an unrepresentable class in $H_2(X,S^1;\mathbb{Z})$ with $\dim X =3$ and $S^1$ highly knotted. When $X=S^3$ this group is $\mathbb{Z}$ (as seen by the LES), and Seifert surfaces do the trick.
As a toy model, consider the equator in a sphere. Then $H_2(S^2,S^1)\cong\mathbb{Z}^2$, as seen by reduced homology $\widetilde{H}_2(S^2/S^1)\cong H_2(S^2\bigvee S^2)\cong H_2(S^2)\oplus H_2(S^2)\cong\mathbb{Z}^2$. It looks like the classes $(1,0)$ and $(0,1)$ come from the hemispheres, and the relative Hurewicz theorem applies I think.