This story begins with the Lefschetz hyperplane theorem - the fact that if $D$ is a smooth, very ample divisor in a closed Kaehler manifold $X$ then $D$ carries all the homology and homotopy of $X$ below the middle dimension of $X$.

One way to understand this theorem is via Morse theory (the Andreotti-Frankel approach). There are explanations in Milnor's "Morse Theory", Griffiths-Harris and elsewhere. The line bundle $\mathcal{O}(D)$ has a canonical section $s$ whose zeroes cut out $D$. One looks at the function $f= - \log \|s\|^2$ on $M=X-D$ (defined via a hermitian metric on the line bundle). This is a bounded-below, proper, strictly plurisubharmonic function; it makes $M$ a Stein manifold. Its critical points (if non-degenerate) all have index $\leq \dim_{\mathbb{C}}X$.

Assuming $f$ Morse, the isotropic skeleton of $M$ with respect to $f$ is the union of the unstable manifolds of the critical points of $f$. Each of these unstable manifolds is isotropic with respect to the Kaehler form (their union may be singular). The downward gradient flow of $f$ will (after a bit of tweaking) define a deformation retraction from $M$ to this skeleton. E.g. for $\mathbb{CP}^{n-1}\subset \mathbb{CP}^n$, the skeleton will be a point.

Very ample divisors are very special; none of this applies to more general divisors. Nonetheless, the story generalizes to symplectic manifolds whose symplectic class in $H^2$ is integral. In this case, Donaldson ("Symplectic submanifolds and almost complex geometry") showed that one can find distinguished symplectic divisors $D$ representing high multiples of the symplectic class. The discussion of the hyperplane complement $M$ is valid also for the complement of a Donaldson hypersurface. The "Stein" condition has to be replaced by something more suitable for almost complex manifolds ("Weinstein") but by a really startling theorem of Eliashberg, Weinstein structures can always be deformed to Stein structures.

For further reading, try Paul Biran's paper
Lagrangian Non-Intersections.