The original problem of Domino Tiling and Wang Tile has great theoretical interest on computability theory... However, the great emerging problem on application of Wang Tile in material science and physics requires the tiling to satisfy one more condition:

The tiling should satisfy some proportionality, say, Tile 1 should appear with frequency 1/16, Tile 2 with frequency 9/16, Tile 3 with 6/16, Tile 4 with frequency 0...

The most important decision problem is the following: Could a given set of Tile tile a grid of size NxN satisfying the frequency constraint within a error of +-epsilon.

For example: could the set {Tile 1, Tile 2, Tile 3, Tile 4} tile the NxN grid with frequency 1/16+-0.01, 9/16+-0.01, 6/16+-0.01, 0+-0.01 respectively....

From one of my previous post:

practical algorithms for np complete problems

I realize the decision problem of tiling without such constraint could be modeled by SAT... With this constraint the problem becomes ridiculously difficult and I eagerly seek for solutions towards this finite decidable problem.... (we could forget epsilon for a moment if the problem with epsilon is too hard)...

Thank you.

For more detail why this problem is practical in material science and physics, see my previous post:

Computational approach deciding whether a set of Wang Tile could tile the space up to some size