If one has a smooth simply connected manifold $M^n$ which we know to bound an $n+1$ dimensional manifold $N$, what can be said about a handle decomposition for one in terms of a handle decomposition for another?

I am particularly interested in the 4 dimensional case. For instance, if we have a closed simply connected smooth 4-manifold which bounds a 5-manifold, can we say anything about a handle decomposition for this 5-manifold?

Thank you

Rob