Back to 1980, P.Erd\H{o}s and C. Pomerance asked in their paper "Matching the natural numbers up to n with distinct multiples in another interval" (see page 160 of the journal scan http://www.math.dartmouth.edu/~carlp/PDF/matching.pdf):

"Related to these questions, we ask if there is a large constant $c$ so that in any interval of length $cn$ there are $\pi(n)-\pi(n/2)$ distinct multiples of the primes in $(n/2, n]$ (there need not be a matching). "

I am wondering if there is any progress on this question. Also, can we say anything if we require only some prime multiples to be present (e. g. we want to guarantee that there are distinct multiples of at least $O(n/\log n)$ primes from $(n/2, n]$)?