Do there exist CWcomplexes $X$ and $Y$ that are not homeomorphic, but $X \times I$ and $Y \times I$ are homeomorphic? Here $I$ denotes the unit interval $[0, 1]$.

Yes. Take $X$ a punctured torus ($T^2\setminus$open disk) and $Y$ a threepunctured $S^2$. Then $X\times I=Y\times I$ is a genus 2 handlebody. 

