Without recourse to the Disc Theorem (or its progeny), is it true that all known examples of exotic differentiable structures on 4-manifolds would be fake rather than exotic?
Terminology (perhaps non-standard):
(1) By "Disc Theorem" I mean the statement, contained in , that kinky handles are not only homotopic to standard 2-handles (as proved by Casson ), but homeomorphic to standard 2-handles,
(2) The "progeny" is all extensions of the Disc Theorem to non-simply connected settings (including gropes, capped gropes, etc),
(3) A smooth 4-manifold is "exotic" if it is homeomorphically equivalent to, but smoothly inequivalent to a standard 4-manifold,
(4) A smooth manifold is "fake" if it is homotopically equivalent to, but smoothly inequivalent to a standard 4-manifold.
The motivation for this question is the same as that of the earlier Question, namely:
The classification  of topological 4-manifolds, which follows from the Disc Theorem, is now 30 years old and an easier version of the proof has not emerged. In contrast, Donaldson's invariants have been followed by more easily computed invariants. This asymmetry is an unsatisfactory state of affairs for such a far-reaching topological result, particularly as it is so regularly used in proof-by-contradiction arguments against results in smooth 4-manifold theory.
As the Bing topologists familiar with these arguments retire, the hopes of reproducing the details of the proof are fading, and with it, the insight that such a spectacular proof affords.
It may be possible to refine the proof under the assumption of more regularity to gain more control over the resulting infinite towers - and perhaps get Hoelder maps rather than homeomorphisms, for example.
 Freedman, M. H. (1982), "The topology of four-dimensional manifolds", Journal of Differential Geometry 17 (3), 357-453.
 Casson, A. J. (1986), "Three lectures on new-infinite constructions in 4-dimensional manifolds", A la recherche de la topologie perdue, Progr. Math., 62, Boston, MA: Birkhauser Boston, 201-244.