Let n be a positive integer greater than 1 and $p_n(x)$ be a polynomial of degree $n$ such that $p(0)= 2, p(1)=3, p(2)=5$, and in general $p(k)$ is the $(k+1)$th prime, for $0\leq k \leq n$.
Is $p_n(x)$ irreducible in $\mathbb Q [x]$?
Let n be a positive integer greater than 1 and $p_n(x)$ be a polynomial of degree $n$ such that $p(0)= 2, p(1)=3, p(2)=5$, and in general $p(k)$ is the $(k+1)$th prime, for $0\leq k \leq n$.
Is $p_n(x)$ irreducible in $\mathbb Q [x]$?
"Most" polynomials are irreducible. More precisely, in this case, the heights of the coefficients of $p_n(x)$ are (at least) exponential in $n$. Among all polynomials of degree $n$ whose coefficients have height on the order of $C^n$ for some fixed $C>1$, only a tiny proportion will be reducible. So once you've checked that $p_n(x)$ is irreducible for the first few $n$, say $n\le10$, it then becomes likely that the rest of them will be irreducible. But I doubt that this has anything to do with the primes. If you took some other "random looking" sequence of integers $a_k$ that grows appropriately and set $p_n(k)=a_k$ for $0\le k\le n$, you should get similar properties. For example, something weird like $a_k=\lfloor \pi (k+1) \log(k+2)\rfloor$.